ZFIN is now using GRCz12tu for Genomic Data

Gene

mbnl2

ID

ZDB-GENE-030131-9582

Name

muscleblind-like splicing regulator 2

Symbol

mbnl2 Nomenclature History

Previous Names

fj89c04
wu:fj89c04

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable RNA binding activity. Acts upstream of or within several processes, including eye development; muscle cell development; and muscle organ development. Predicted to be located in nucleus. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in several structures, including chordo neural hinge; gonad; nervous system; pectoral fin bud; and solid lens vesicle. Used to study myotonic disease. Orthologous to human MBNL2 (muscleblind like splicing regulator 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mbnl2 Human Ortholog

No data available

Associated With mbnl2 Via Experimental Models

Human Disease	Fish	Conditions	Citations
myotonic disease	WT + MO2-mbnl2	standard conditions	Machuca-Tzili et al., 2011
myotonic disease	WT + MO3-mbnl2	standard conditions	Machuca-Tzili et al., 2011
myotonic disease	mbnl2^b1360/b1360	standard conditions	Hinman et al., 2021
myotonic disease	WT + MO4-mbnl2	standard conditions	Machuca-Tzili et al., 2011
myotonic disease	WT + MO1-mbnl2	standard conditions	Machuca-Tzili et al., 2011

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000571	Zinc finger, CCCH-type
Domain	IPR041367	E3 ligase, CCCH-type zinc finger
Domain	IPR054429	Muscleblind-like, CCCH zinc finger

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:F1Q5U6	InterPro	208
UniProtKB:B8JIV1	InterPro	371
UniProtKB:A0A8M2BFL2	InterPro	388
UniProtKB:A0A8M9PUY2	InterPro	351
UniProtKB:A0A8M3AWR8	InterPro	383
UniProtKB:A0A8M3B692	InterPro	365
UniProtKB:A0A8M9Q0X5	InterPro	369
UniProtKB:A5YC70	InterPro	339
UniProtKB:B7ZUV4	InterPro	357
UniProtKB:A0A8M3BD13	InterPro	370
UniProtKB:A0A2R8QF26	InterPro	190
UniProtKB:A0A8M3B3A3	InterPro	376
UniProtKB:A0A8M3BD19	InterPro	353
UniProtKB:A0AC58J713	InterPro	388
UniProtKB:A0AC58J718	InterPro	388
UniProtKB:A0AC58J722	InterPro	383
UniProtKB:A0AC58J728	InterPro	383
UniProtKB:A0AC58J732	InterPro	383
UniProtKB:A0AC58J747	InterPro	376
UniProtKB:A0AC58J757	InterPro	376
UniProtKB:A0AC58J760	InterPro	376
UniProtKB:A0AC58J766	InterPro	371
UniProtKB:A0AC58J769	InterPro	376
UniProtKB:A0AC58J783	InterPro	371
UniProtKB:A0AC58J788	InterPro	371
UniProtKB:A0AC58J794	InterPro	370
UniProtKB:A0AC58J799	InterPro	371
UniProtKB:A0AC58J7A0	InterPro	370
UniProtKB:A0AC58J7A4	InterPro	370
UniProtKB:A0AC58J7A5	InterPro	370
UniProtKB:A0AC58J7B4	InterPro	370
UniProtKB:A0AC58J7C1	InterPro	369
UniProtKB:A0AC58J7D0	InterPro	365
UniProtKB:A0AC58J7D4	InterPro	365
UniProtKB:A0AC58J7D9	InterPro	369
UniProtKB:A0AC58J7E4	InterPro	365
UniProtKB:A0AC58J7F0	InterPro	365
UniProtKB:A0AC58J7F4	InterPro	358
UniProtKB:A0AC58J7G1	InterPro	365
UniProtKB:A0AC58J7G2	InterPro	358
UniProtKB:A0AC58J7G7	InterPro	358
UniProtKB:A0AC58J7I0	InterPro	357
UniProtKB:A0AC58J7J0	InterPro	357
UniProtKB:A0AC58J7J1	InterPro	353
UniProtKB:A0AC58J7J8	InterPro	353
UniProtKB:A0AC58J7K9	InterPro	353
UniProtKB:A0AC58J7M5	InterPro	353
UniProtKB:A0AC58J7N3	InterPro	353
UniProtKB:A0AC58J7P2	InterPro	351
UniProtKB:A0AC58J7Q4	InterPro	351
UniProtKB:A0AC58J7R0	InterPro	339
UniProtKB:A0AC58J7R2	InterPro	339
UniProtKB:A0AC58J7R7	InterPro	339

Transcripts

Genome Browsers

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	mbnl2-201 (1) Ensembl	Ensembl	1,630 nt	Select Tool ZFIN BLAST
mRNA	mbnl2-202 (1) Ensembl	Ensembl	1,400 nt	Select Tool ZFIN BLAST
mRNA	mbnl2-203 (1) Ensembl	Ensembl	1,237 nt	Select Tool ZFIN BLAST
mRNA	mbnl2-204 (1) Ensembl	Ensembl	4,028 nt	Select Tool ZFIN BLAST
mRNA	mbnl2-205 (1) Ensembl	Ensembl	5,065 nt	Select Tool ZFIN BLAST
mRNA	mbnl2-206 (1) Ensembl	Ensembl	919 nt	Select Tool ZFIN BLAST
mRNA	mbnl2-207 (1) Ensembl	Ensembl	734 nt	Select Tool ZFIN BLAST
mRNA	mbnl2-208 (1) Ensembl	Ensembl	715 nt	Select Tool ZFIN BLAST
mRNA	mbnl2-210 (1) Ensembl	Ensembl	643 nt	Select Tool ZFIN BLAST
mRNA	mbnl2-211 (1) Ensembl	Ensembl	3,932 nt	Select Tool ZFIN BLAST
mRNA	mbnl2-212 (1) Ensembl	Ensembl	3,539 nt	Select Tool ZFIN BLAST
mRNA	mbnl2-213 (1) Ensembl	Ensembl	1,175 nt	Select Tool ZFIN BLAST
mRNA	mbnl2-214 (1) Ensembl	Ensembl	3,485 nt	Select Tool ZFIN BLAST
ncRNA	mbnl2-003 (1) Ensembl	Ensembl	720 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Genome Browsers

NCBI Map Viewer

ZFIN

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations